Trevor Hughes is working in Pakistan with an organization called Secured Path. He has a blog where he is regularly posting on the lastest from the ground in the areas hit by the earthquake. He also recommends donations to the International Medical Corps. It seems to be a solid organization and it clearly is involved in parts of our world that are in the greatest need, including Afghanistan, Iraq, Sudan, Pakistan, and a number of countries in Africa. Here’s a link to a brochure.